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1. SCIENCE PRESENTATION 2. OUR WORLD-CLASS SCIENCE • Proprietary science with more than 30 years of anti-aging research • Large team of expert in-house scientists • Collaborations with leading research institutions • Specialties in skin care and nutritional product science with extensive product portfolios in each • Focus on targeting sources—not just the symptoms—of aging 3. OUR INNOVATION THROUGH 2015 4. Aging Signs And Symptoms Aging Sources TRADITIONAL APPROACH TO ANTI-AGING SCIENCE NU SKIN® APPROACH TO ANTI-AGING SCIENCE Treat signs and symptoms Identify and address the sources of aging NU SKIN’S APPROACH TO ANTI-AGING SCIENCE 5. 2008: Focused on arNOX suppression A HISTORY OF INNOVATION 6. ARNOX SUPPRESSION Free radicals are unstable molecules that can cause skin aging. We’re exposed to them through pollution, UV radiation, stress, and many other factors. We also produce them naturally inside our bodies. Many of the free radicals inside our bodies are produced through an enzyme called Age-Related NADH Oxidase (arNOX). In 2008, Nu Skin began developing formulations to suppress arNOX and its production of free radicals. 7. 2009: Identified Facial Skin YGCs 2008: Focused on arNOX suppression A HISTORY OF INNOVATION 8. OUR UNIQUE UNDERSTANDING OF GENE EXPRESSION DNA Microarray Gene Map Over 20,000 Genes Heatmap 1. The breakthrough mapping of the Human Genome allows scientists to look at an entire set of genes within the DNA. 2. Nu Skin’s proprietary understanding allows us to focus on specific sets of genes to interpret and understand their expression. 9. PCR Amplification GraphPCR Plate PCR Data WE MONITOR GENE EXPRESSION OVER TIME The PCR plate allows scientists to monitor how genes react over time, giving a clearer and better understanding of gene expression overall. 10. WE ILLUSTRATE RESULTS 11. IDENTIFIED FACIAL SKIN YGCS ANTI-AGING SCIENCE Skin Structure Pigmentation Hydration Cell Turnover Lines & Wrinkles Skin Structure Discoloration Uneven Skin Tone Hydration Smoothness, Texture Radiance Pore Size 12. 2011: Identified Body Skin YGCs 2009: Identified Facial Skin YGCs 2008: Focused on arNOX suppression A HISTORY OF INNOVATION 13. IDENTIFIED BODY SKIN YGCS LOOK YOUNG • Decreased Appearance of Cellulite • Firming • Lifting • Smoothing • Hydrating Appearance of cellulite = Depth extent, surface texture. BODYYOUTHGENECLUSTER Targetsgenesresponsiblefor: MOVEMENT OF FLUID SKIN STRUCTURE HYDRATION LIPID METABOLISM ANTI-AGING SCIENCE 14. 2012: Expanded Facial Skin YGCs to include firming 2011: Identified Body Skin YGCs 2009: Identified Facial Skin YGCs 2008: Focused on arNOX suppression A HISTORY OF INNOVATION 15. ANTI-AGING SCIENCE Skin Structure & Firming Pigmentation Hydration Cell Turnover Lines & Wrinkles Skin Structure Firming Discoloration Uneven Skin Tone Hydration Smoothness, Texture Radiance Pore Size EXPANDED FACIAL SKIN YGCS TO INCLUDE FIRMING 16. AGELOC ME™ CLINICAL TESTING • Safety is key. Our Clinical Lab performed more than 200 sting and irritation safety tests in 2014. • Efficacy is proven. We conducted 50+ in-house exploratory or confirmatory in- house clinical studies in 2014, lasting from one day to 16 weeks in duration. • Results are validated. In 2014, we conducted more than 200 studies or tests at third-party research facilities. 17. AGELOC ME™ FORMULATIONS In 2014, we: • made over 700 laboratory batches • worked on 170 different formulas • created up to 50 different iterations per formula • sent 279 batches/formulas through Microbiological Challenge Test Protocol • tested over 11,000 micro plates • tested over 370 batches for stability
