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SOUTH AFRICAN PHARMACEUTICAL & COSMETIC REVIEWApril 2018 | Volume 45 | Number 4www.pharmacos.co.zaInnovative products and solutions for pharma and nutraceutical formulationsWhat you missed at #PCRConference2018!GO LEAN & GREEN:Cold process materials for your formulations Trends, ingredients and technology for OTCs“‘My experience at Bonpak and Scentlab has been wonderful. The products are affordable compared to other companies in the industry. Also, equally important is the consistency in the quality of products we receive like the alcohol compound, which enhances the trust and reliability of these companies. I am truly a satisfied customer’ – Mzuqhamile Mbangi, Instil Perfumes.The best quality at the best price A strong and positive affiliation between three independent companies has created a one-stop shop of distinction for cosmetic brands and entrepreneurs. Management at Bonpak, Enterprise Ethanol and Scent Lab in Gauteng has more than 80 years combined industry knowledge, which is applied to find custom solutions their customers. Sourcing fine fragrances, ethanol for yournot only create an enabling environment -brand, product or range – it is what keepsperfume base, packaging and brand designa central point where customers can findcustomers returning and drives sales.’solutions at competitive prices, within asolutions for their packaging, fragrance andThe dynamic trio of companies alsocentral hub, is possible. How? Through theethanol requirements – but also eliminateshas a strong African profile. This allowsaffiliation between Bonpak, Enterprisethe hassle of having to source productsit to transport with ease items with highEthanol and Scent Lab. Customers can tapand ingredients from different locations.compliance criteria, like ethanol, to anyinto the service and expertise each companyAlso, being able to work with trusted anddestination on the continent. Complianceoffers individually, while benefitting fromproven companies like these demystifies theand safety consulting is available to ensurethe collective symbiotic relationshipprocess. Testing facilities are available forthat companies are compliant with the law.established between the three companies.customers to validate the grade of products,Being flexible in trade means that there areultimately ensuring a premium product.no restrictions in sourcing products globally.one ethos: to continually grow customers’Scent Lab is willing to test any product and‘We can source globally and package locally,’businesses by helping them achievetogether with Bonpak and Enterprise Ethanolaccording to the owner of ScentLab.premium quality at affordable pricing withinoffer advice to customers on how to get thetheir market segment. The synergy hasbest quality at the best price.Each of these companies work towardsworked well for the existing customer base,The companies work with hard facts andDespite rapid growth, the three companies have never compromised the efficiency and convenience with which theywhich finds value in sourcing everythinguse economies of scale to make sure theserve their customers. ‘Global sourcing,needed to develop a product from a centralcustomer’s demands are met or exceededinventory, flexibility and total solutions or,hub of the three affiliated companies.while creating a consistency in productin short, a GIFT, is what they collectively canthat will boost their clients’ reputationdeliver – consistently offering the customersSUPPLIER HUBas a manufacturer of a reliable, qualitythe best advice, quality products andBonpak, founded and owned by Ray Bondi,product. ‘A consistent product range insolutions that will fit their needs,’ states theis the largest glass and plastic containerterms of quality is vital to the success of anydirector of Bonpak.distributor to the pharmaceutical, cosmetic and food industries. Enterprise Ethanol supplies 99.9 percent pure ethanol on a large scale, while Scent Lab supplies fine fragrance aroma compounds as pure A-grade perfume oils on a global scale. Bonpak’s ability to support bottle and logo design via an in-house design team rounds off the professional services available to customers. ‘We create an enabling environment, a central point where customers can find solutions for their packaging, fragrance and ethanol requirements at below market prices.’ The belief is that these three companiesGrowing our business for our customers businessBonpak’s continued success is based on efficient service delivery, vast product offering and determination to meet its customers business desires through investing in understanding their needs. The company also works closely with its customers to help them achieve their ambitions in the market. Market solutions: • flexible pricing • broad product range and available stock • Certificate of Conformity (COC) and Certificate of Analysis (AOA) accredited • able to service large quantity orders.Scent Lab is able to procure the highest quality compounds for the best price from various sources. This ensures the best pricing for the best quality for its customers. Scent Lab does not conform to the clichéd agency agreement thus enabling the company to secure the optimum overall offering for its customers. Market solutions: • competitive pricing • innumerable quantities • expert advice on mixing, formulating and packaging of perfume products.An obsession for a pure product and efficiency is at the core of Enterprise Enthanol’s business practices. The company has thousands of satisfied manufacturing customers, from perfumers to pharmaceutical manufacturers, which use its ethanol daily in their products. Its low-cost business model as well as efficient storage and drumming plant are modern and lean, allowing the company to pass the benefit onto the customer in the form of low prices – historically on average, customers save 16.7 percent on their ethanol spend. Market solutions: • product appropriation, denaturing to the clients’ requirements in line with local excise laws • cost-effective pricing • short lead times for delivery of drummed product across South Africa • compliance and safety consulting available to ensure regulations are met • a tank installed and managed at customer’s premises • bulk management systemswww.bonpak.co.za | www.enterpriseethanol.co.za | www.scentlab.co.zaLaunched a new product in 2017/18?ENTRIES NOW OPENContact Natalie Da Silva:
[email protected] | +27 (0)11 877 6281Contents SOUTH AFRICAN PHARMACEUTICAL & COSMETIC REVIEWApril 2018 | Volume 45 | Number 4w w w.pharmacos.co. za7 NEWS Rain Africa celebrates Fair Trade Guaranteed status SAMRC to develop African Genomics Centre Farmovs-Parexel acquired by the University of the Free State21Efficient for effervescentsFlexible solutions11 PRODUCT NEWS What’s new in South Africa12 EVENTS Ashland and IMCD SA’s interactive hair care seminar Highlights from the P C Review conference18 FORMULATOR’S CORNER for controlled environments35 28 PERSONAL CAREIntroducing The Cosmetics Chef… Symrise meets cold-process needs with Dracorin GOC Local contract manufacturer shapes its international appeal19 PHARMA FOCUS: OTCs OptiPEA – a proven natural ingredient for pain relief Naturally derived emollients and emulsifiers from Savannah How to compress effervescents with Romaco Kilian Cama launches flexible line for personal care industry New patch for pain care Seppic introduces the dedicated wesource brand Make a splash in formulations with coconut water24 HOME CARE Albex Noflush helps consumers save water35 CLEANROOM CONTROL Sodium ATB-base polymer for all-purpose cleaners Flexible solutions for controlled environments Alcohol-based surfactants from Protea Chemicals Hugo Beck ensures hygiene standards39| Volum April 2018e 44 | Number4W PackagingREVIERICAN SOUTH AFSupplier brand owner synergycos.co.za www.pharmafor success42 Installation Zippy Labels ramps up production with 11 new machines44 Bottles, Tubs & Jars45 How to achieve success with your suppliers Adapt to trends and industry developmentsss Airple umps A ND mini packasy lead the w ace How surfen ion hances fluorinat c packaging plasti48 ASSOCIATION NEWS The latest news from the HPA, SAAFFI and Coschemls installsZippy Labe nes 11 new machiP C Review | APRIL 2018 |5SOUTH AFRICAN PHARMACEUTICAL & COSMETIC REVIEWFrom the editorTHE TEAMTheEDITORIALcold process approachAre you wondering what all theand Protea Chemicals’ alcohol-basedhype is about cold processablesurfactants for hard surface cleaning.emulsifiers and emollients in the personal care industry? Well, itIf you missed out on attending this year’s P C Review Beauty Trends & Innovationmakes perfect sense to opt for cold processconference, we’ve included a roundup ofmaterials to reduce your manufacturingthe event on page 14. Another formulatorcosts and implement leaner and greeneris featured this month on page 18. Connyproduction methods. As a formulator,Obberauter aka The Cosmetics Chef talkssurely you want to skip the unnecessaryabout how she’s empowering people tosteps to achieve your goal of building acraft their own beauty products usingunique product? Now you can, with thenatural and organic ingredients as well ascold process materials highlighted in thea kitchen blender.Personal Care feature in this edition of PharmaceuticalCosmetic Review. OnThere is a lot of interesting content instore for our pharma industry readers inEditor: Abby Vorster +27 (0)11 877 6038
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[email protected] Layout & Design: Kirsty Thomas Contributors: Charmaine du Preez, Peter Heyn, Sally Harvey ADVERTISING Sales Executive: Carla Melless +27 (0)83 260 6060
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[email protected] 28, you can read more about howthis edition. We look at over the counterEcocert approved Dracorin GOC fromproducts and their associated processingSymrise, IQL’s Soldoc PG 410 and Soldoctechnologies and ingredients in thePGPR polyglyceryl esters and Vantage’sPharma Focus on page 19. We discussDistinctive Coconut Water can contributeequipment, garments and accessories forPUBLISHING TEAMto substantial energy and productioncontrolled environments in this month’sGeneral Manager: Dev Naidoocost savings, fewer CO2 emissions and aCleanroom Control feature.reduced environmental impact. Dwindling water resources have resultedIn our regular PACKAGING REVIEW section, we highlight industry trends andin an upswing in waterless cleaningdevelopments in the Bottles, Tubs and Jarsproducts. In the Home Care feature onfeature (page 44) and celebrate Zippypage 24, we share the story of AlbionLabels’ revival with its most recent string ofBrands’ latest innovation, Albex Noflush,installations (page 42) at its new printingwhich neutralises the smell of urine,facility, after enduring a devastating floodallowing consumers to ‘let it mellow whenin November 2016.yellow’. We also highlight a range of solutions for household cleaning products,CIRCULATION Circulation Manager: Felicity Garbers +27 (0)21 701 1566
[email protected] Manager: Natalie Da Silva +27 (0)11 877 6281
[email protected] Production Controller: Rae Morrison Art Director: David Kyslinger JOHANNESBURG OFFICE New Media Publishing, Ground floor, Media Park, 69 Kingsway Avenue, Auckland Park, 2092 Tel: +27 (0)11 877 6111, Fax: +27 (0)11 877 6198 POSTAL ADDRESS PO Box 784698, Sandton, Johannesburg, 2146 Published on behalf of Media24 by New Media Publishing (PTY) Ltd. MANAGING DIRECTOREnjoy the read.Aileen Lambincluding Chemical Initiatives’ ready to useCHIEF EXECUTIVE OFFICERconcentrated dispersion for liquid laundryBridget McCarneydetergents and dishwashing products,EXECUTIVE DIRECTOR John Psillos NON-EXECUTIVE DIRECTOR Irna van ZylEDITORIAL ADVISORY BOARDHEAD OFFICE New Media House, 19 Bree Street, Cape Town 8001 Tel: +27 (0)21 417 1111, Fax: +27 (0)21 417 1112 Email:
[email protected] PO Box 440, Green Point, Cape Town 8051Consultant, drbaileys.comDr Trevor BailliePast-President, Society of Cosmetic Chemists SAProf Dr Aubrey ParsonsJohn KnowltonCEO of the Generic and Biosimilar Medicines of Southern AfricaProfessor Emeritus, Faculty of Health Sciences, Nelson Mandela UniversityVivian FrittelliProf N T (Raj) NaidooP C Review is the official journal of: CTFA - The Cosmetic, Toiletry & Frangrance Association of South Africa GBM - Generic and Biosimilar Medicines of Southern Africa6Consultant, Cosmetic Solutions| APRIL 2018 | P C ReviewCOSCHEM - The Society of Cosmetic Chemists of South Africa HPA - The Health Products Association of Southern Africa AMA - The Aerosol Manufacturers’ Association of South AfricaPharmaceutical Cosmetic Review is published by New Media Publishing 11 times a year and circulates to manufacturers, packers and distributors of pharmaceuticals, health products, cosmetics, detergents, soaps, toiletries and allied products. The journal is an up-to-date source of reference for company directors, factory and production managers, marketing executives, engineers, import agents, buyers and research personnel. While precautions have been taken to ensure the accuracy of its contents and information given to readers, neither the editor, publisher, or its agents can accept responsibility for damages or injury which may arise therefrom. All rights reserved. © Pharmaceutical Cosmetic Review. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, photocopying, electronic, mechanical or otherwise without the prior written permission of the copyright owners. Pharmaceutical Cosmetic Review is printed and bound by CTP Printers - Cape Town. Copyright: all rights reserved. ISSN 0257-8719Opt for Verderflex hoses for extended hose lifeAVOID HOSE FATIGUE WITH VERDERFLEX HOSESSOME HOSE PUMPS have short lifespans but Verderflex offers extended hose life beyond that of its competitors. Hoses fail for one reason – fatigue. ‘Although there can be many reasons for hose failure, fatigue is one of the main seasons. Speed, discharge pressure and temperature are all influencing factors that increase hose fatigue,’ says a representative from Verder Pumps. After eight to 12 million cycles, a hose will fail to return to its spherical shape after compression. This is evidenced first by a reduction in flow, then physical deterioration of the hose. Verderflex’s Dura pump series has several design features that provide longer hose life than competitor products. Three times more nylon reinforcing fibers are input into the hose during the manufacturing process. With more fibres, the compression load is spread reducing stress per fibre and extending fatigue life. According to Verder Pumps, it is the only manufacturing that includes additional nylon reinforcingFair Trade GuaranteedNEWSstatus for Rain Africa HANDCRAFTED BATH, BODY and home care brand, Rain Africa’s Fair Trade accreditation with the global World Fair Trade Organisation based in Europe is one of its greatest accomplishments. It’s not easy to achieve this kind of global accreditation and to maintain it, ongoing auditing and continual improvement plans and accountability are required. Ultimately, Fair Trade accreditation requires unwavering dedication to its principles. Every two years, members are assessed and reviewed by the organisation and their piers which includes onerous scrutiny on every level. Subsequent to the auditing process, Rain has been awarded Fair Trade Guaranteed status, which is the highest level of Fair Trade Accreditation. Rain Africa’s employees are extremely proud of the company’s Fair Trade Guaranteed statusfibers in its hoses, which are handmade to the correct tolerances and do not require any machining. Verderflex hoses are made with 100 percent EPDM, giving them increased temperature resistance and preventing a liner weak point. The Dura pump incorporates an air-gap design, also unique to Verderflex. While the gearboxes in traditional-style hose pumps are flange-mounted to the pump housing, Verder uses a torque arm connection to ensure a physical separation exists between the pump and drive. This prevents heat that builds up in the drive from being conducted into the pump housing. ‘Superior Verderflex hoses are available for many competing pumps,’ the representative concludes.EXTREME EFFICIENCIES WITH THE LOWEST OPERATIONAL COST AND THE WIDEST PRODUCT OFFERING WITHIN THE PHARMACEUTICAL INDUSTRY.Verder pumps.indd 12018/03/27 9:07 AMP C Review | APRIL 2018 |7NEWS2017 a recordbreaking year for biosimilar approvalThe number of biosimilars first approved between 2013 and 2017 in the US, Japan, or the EUSA GENOMICS CENTRE TO ENABLEPERSONALISED MEDICINETHE AFRICAN GENOMICS Centre – a first for South Africa – is already under construction at the South African Medical Research Council (SAMRC) head office in Cape Town. In February, SAMRC cemented its collaboration with the Beijing Genomics Institute (BGI), signing a formal agreement that guarantees an exciting future for this state-of-the-art research facility. BGI is at the forefront of the global scientific progress on genetic science and DNA sequencing, while South Africa has identified an opportunity through this partnership to build the country’s capacity for whole human genome sequencing. ‘The development propels South Africa into a new era of medical research and means that we join a small, but growing, group of countries that are pioneering this type of innovation,’ says Professor Glenda Gray, SAMRC president. The signing ceremony took place on 16 February on top of Table Mountain in Cape Town. Prof Gray comments: ‘This novel field of research harnesses the science of genomics for personalised medicine. Knowledge of the DNA sequence has become an important part of understanding disease. By establishing the sequence of an individual’s genetic material, it isTHE NUMBER OF first approvals for biosimilars in the US, Japan, or the EU has increased significantly in the past two years, breaking the stagnation of the three years prior. In 2017 a new record was set for the number of first approvals in a single year, according to GlobalData, a leading data and analytics company. The FDA alone approved five new biosimilar products, seeing the number of approved biosimilars in the US rising from four to nine. This includes two products for Oncology use: Mylan and Biocon’s Ogivri, which is a biosimilar to Genentech’s Herceptin and Amgen and Allergan’s Mvasi – a biosimilar to Genentech’s Avastin. The European Medicines Agency (EMA) approved eight new biosimilars, including biosimilars of AbbVie’s Humira, Genentech’s Rituxan, Herceptin, Eli Lilly’s Humalog (insulin lispro injection), and Eli Lilly’s Forsteo. With 23possible to identify mutations which are specific to that person. These genetic tools will help us understand South Africa’s diverse gene pool and convey insights on treatments for common diseases like diabetes.’ The centre will be a vital national asset, able to contribute to better understanding factors that impact on the health of South Africans and inform strategies to improve their response to diseases. This means conditions that contribute to the heavy disease burden in the country – such as hypertension, stroke, heart disease, diabetes and cancer – can be diagnosed faster and more accurately. Treatments can also be delivered in a more targeted, effective and costefficient way. Dr Li Ning, BGI’s chi
